• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Vibrating mesh nebulizer device for drug application, comprising a housing (10), a mouthpiece (5), a nebulizer (4) and a chamber that houses a drug, wherein said chamber that houses a drug is a disposable capsule ( 1) forming an independent and removable body of the housing of the device, wherein said disposable capsule (1) comprises means for attachment to the nebulizer (4) and the housing (10), wherein said fixing means allow coupling/uncoupling the capsule disposable (1) to the nebulizer device. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2567954A1
    申请号:ES201431415
    申请日:2014-09-26
    公开日:2016-04-26
    发明作者:Juan José SALEGUI ECHEVESTE；Iñaki SALEGI ETXEBESTE
    申请人:Juan José SALEGUI ECHEVESTE；Iñaki SALEGI ETXEBESTE；
    IPC主号:
    专利说明:

    DESCRIPTION

    Nebulizer device

    Object of the invention 5

    The present invention relates to a vibrating mesh nebulizer device.

    The nebulizer devices are used in the pharmaceutical and hospital industry to administer medications by inhalation, preferably orally, in the form of a dispersion of small liquid particles in the form of mist and expelled through a nozzle of said nebulizer device.

    The patient who is following a certain treatment in which it is necessary to make use of a nebulizer device, inhales, through said nebulizer device, the precise dose of the medication that has been prescribed.

    The present invention therefore finds application in the field of the pharmaceutical and hospital industry and, in general, in the industry dedicated to the manufacture, distribution, marketing and administration of medicaments. twenty

    Technical problem to be solved and Background of the invention

    In the state of the art there are different procedures and devices for administering medications via aerosols or sprays (also called 25 atomizers or nebulizer devices).

    An example of a nebulizer or atomizer device can be found described in US Patent US 8025050 B2, which describes a nebulizer cartridge with a geometry <designed to take full advantage of the medicament contained in said cartridge.

    As regards the procedures for the administration of drugs via aerosols or nebulizers, one of said procedures consists in dispersion or nebulization by means of a vibrating mesh.

    In this type of nebulizer devices, the aerosol is generated by pushing the liquid medication through the micro-holes that exist in a metallic or polymeric alloy mesh, according to each case, where said mesh is oscillated at high frequency (~ 180 kHz)

    The advantages of this technology can be summarized in: 10

    - an adequate size of nebulized particles is achieved;

    - ease of transport, due to its pocket size;
     fifteen
    - operation with conventional batteries;

    - inhalation at various angles of attack with a stable mist (easy to use in bed, or with a child or baby in arms);
     twenty
    - silent operation;

    - simple operation, by pressing a single button;

    - valid for a wide range of medicines; 25

    - minimum losses and residues of the medication (around 0.1 ml).

    However, despite the above-mentioned advantageous characteristics, the vibrating mesh nebulization technology currently finds some 30 disadvantages, such as the need to clean and disinfect the nebulizer device once the medicine it contains is inhaled. This implies that it is necessary to access the largest possible number of internal points of the device
    nebulizer, including the mouthpiece and chamber (receiver chamber) into which the drug that has to be administered is introduced.

    Another drawback that these devices have, is that both the mixture of the medication that is introduced into the chamber, and the dose of said medication, is frequently prepared by the patient himself at home, which sometimes causes errors in the dose, resulting in not getting the right treatment.

    Finally, it is also common that the design of the bedroom does not facilitate the complete taking of the medication dose, which also results in inadequate or insufficient treatment.

    Description of the invention
     fifteen
    The present invention relates to a nebulizer device, of the type comprising a vibrating mesh for the nebulization of a medicament contained therein, to be administered in aerosol form to a patient.

    The nebulizer device object of the present invention is formed by a housing, a mouthpiece (through which the patient inhales the medicine), a chamber that houses the medicine inside, and a nebulizer comprising the mesh inside vibrant.

    The most unique feature of the nebulizer device presented is that the chamber that houses a medicine inside is a disposable capsule that forms an independent and removable body from the housing of the nebulizer device, where said disposable capsule comprises fixing means both to the nebulizer and to the housing of the device, such that said fixing means allow the disposable capsule to be coupled and / or uncoupled to the nebulizer device 30.

    In a first embodiment of the nebulizer device, said fixing means comprise a threaded coupling between the nebulizer and the disposable capsule.

    Alternatively, said coupling can be made without thread, by pressure and tightening. 5 In the latter case, according to a possible embodiment of the device, the nebulizer comprises a hinge that attaches it to the disposable capsule.

    The same types of threaded or pressure coupling and tightening (by means of a correct tightening diameter at the end of the nozzle that connects to the nebulizer and / or the disposable capsule) are also valid embodiments for coupling between the nozzle and the nebulizer and / or the disposable capsule.

    In an alternative embodiment, the nozzle can be coupled to the housing of the nebulizer device 15, according to the coupling means described.

    Alternatively, the nozzle of the nebulizer device may be an integral part of the housing of the nebulizer device.
     twenty
    While the present invention provides for the disposable capsule (1) to be discarded after each use of the nebulizer device, the nebulizer (4) of the nebulizer device is preferably reusable.

    The nebulizer, as already mentioned, comprises in its interior the vibrating mesh 25 for the nebulization of the medicament.

    Likewise, according to a preferred embodiment of the nebulizer device, the nebulizer also comprises a piezoelectric, which drives the vibrating mesh. Said piezoelectric is activated by means of activation / deactivation means 30 which, according to an embodiment of the nebulizer device, can consist of a button present in the housing of the nebulizer device.

    The disposable capsule is removably inserted into the housing, either being completely hidden inside the housing, or partially peeking out of said housing.

    Also, it should be mentioned that the medicine contained inside the disposable capsule 5 can be formed by a single phase, liquid, or by two or more phases (liquid or combination of solid and liquid), separated by at least one internal seal of the disposable capsule.

    Likewise, the nebulizer preferably comprises a punch with a cutting end 10, which, when the nebulizer is coupled to the disposable capsule of the nebulizer device, pierces an external seal of the disposable capsule (in case it has not been manually removed) and / or the less an internal seal of said disposable capsule (in those embodiments in which the disposable capsule comprises at least one internal seal), accessing the medicine contained therein, and mixing the different phases that, if any, could form said medication.

    Said punch comprises a preferably hollow geometry, which allows the medicament to circulate or flow inside, towards the vibrating mesh of the nebulizer and, finally, towards the outside of the nebulizer device.

    According to a preferred mode of operation of the nebulizer device, the user places the nozzle of the nebulizer device in the mouth and activates the activation / deactivation means (eg a button in the housing) that activate the piezoelectric 25 which in turn vibrates the vibrating mesh of the nebulizer of the nebulizer device. Subsequently, the user of the nebulizer device aspirates and inhales the powdered medication, which enters into his body.

    The external seal fulfills the function of sealing the medicine that contains the disposable capsule inside.

    In those embodiments in which the disposable capsule comprises at least one internal seal, each internal seal of the disposable capsule performs a function.
    of sealing the medicine that said disposable capsule contains inside and / or a function of separating the different phases (solid / liquid) that can form said medicine.

    The outer seal is preferably located at the end of the disposable capsule 5 that connects to the nebulizer.

    The geometry of the disposable capsule is preferably vertical conical (funnel shape) in its upper part and cylindrical in its lower part that connects with the nebulizer, being able to present a bending that joins the upper vertical conical part 10 with the lower cylindrical part.

    The lower cylindrical part of the disposable capsule may be in an upright position (like the upper conical part).
     fifteen
    In the embodiment in which the disposable capsule comprises a bend between the upper conical part and the lower cylindrical part, said lower cylindrical part can be arranged obliquely or horizontally.

    Brief description of figures 20

    As part of the explanation of the embodiment of the invention, a series of figures are included, the explanation of which is as follows:

    Figure 1: Shows an exploded perspective view of a first embodiment of the nebulizer device object of the present invention.

    Figure 2: Shows a sectional view of a second variant of the first embodiment of the nebulizer device.
     30
    Figure 3: Shows a perspective view of a third variant of the first embodiment of the nebulizer device.

    Figure 4: Shows a perspective view of a first type of housing of the nebulizer device, in which the main components of the nebulizer device object of the present invention can be integrated.

    Figure 5: Shows a perspective view of assembly of the main components 5 of the nebulizer device object of the present invention in the housing shown in Figure 4.

    Figure 6: Shows a perspective view of assembly of a second embodiment of the nebulizer device in a second type of housing. 10

    Detailed description

    The present invention relates, as already mentioned, to a vibrating mesh nebulizer device. fifteen

    The nebulizer device comprises, in any of the embodiments described below, a housing (10), a disposable capsule (1), a nebulizer (4) and a nozzle (5).
     twenty
    The nebulizer device also comprises an external seal (3) of the disposable capsule (1) and, optionally, at least one internal seal (2) of the disposable capsule (1).

    The nebulizer (4) in turn comprises a punch (6), a piezoelectric (7) and a mesh 25 (8).

    In the first embodiment, the disposable capsule (1) has an angled geometry preferably with a vertical conical shape at the top, and with a horizontal cylinder shape at the bottom, plugged by an external seal (3). 30

    Figure 1 shows, in exploded perspective, the first embodiment of the nebulizer device (the housing (10) has not been shown). In that figure
    the fundamental elements that are part of the nebulizer device can be seen, according to said first embodiment.

    In Figure 1, a disposable capsule (1) comprising an external seal (3) and a single internal seal (2) is shown. 5

    In cases where there is a single internal seal (2), it fulfills the mission of preserving the medicine contained inside the disposable capsule (1) from the outside environment, once the external seal (3) has been removed, either voluntarily, or because of its deterioration. Note that, preferably, the external seal 10 (3) comprises means, such as a small flange or flap, which allow said external seal (3) to be manually removed. Therefore, during transport and / or storage of the disposable capsules (1), said external seal (3) could be damaged by friction with some external element, accidentally removing the external seal (3) from the disposable capsule (1). In such a case, the existence of an internal seal (2) guarantees the sealing and preservation of the medicine inside the disposable capsule (1).

    In cases where there is more than one internal seal (2), the internal seals (2) located more inward of the disposable capsule (1) fulfill the function of separating different phases in which the medicine could be stored contained inside the disposable capsule (1). Said phases may comprise liquid phases, or a combination of solid and liquid phases.

    There is also the possibility (not shown) that the disposable capsule (1) does not comprise any internal seal (2), and only comprises an external seal (3) that performs the function of preserving the medicament contained inside the capsule disposable (1) from the outside environment.

    The nebulizer (4) can form a single body with the disposable capsule (1) of the nebulizer device, so that both the nebulizer (4) and the disposable capsule (1) are disposable once the dose of medication that has been consumed is consumed. It houses the disposable capsule (1).

    Alternatively (and preferably), the nebulizer (4) is removable from the disposable capsule (1), once the dose of medicine that houses said disposable capsule (1) has been consumed.

    In this way, the nebulizer (4) is reusable and material and costs are saved for the user, since the latter does not have to acquire a new nebulizer (4) for each use of the nebulizer device, and it is not necessary to clean the disposable capsule (1) after using the nebulizer device; Simply clean and disinfect the nebulizer (4) after use, and you only need to purchase disposable capsules (1) at your pharmacy or outpatient, which attaches to the nebulizer (4) 10 for the administration of the appropriate medication.

    The nozzle (5) can also form a single body with the nebulizer (4) and / or with the disposable capsule (1) and / or with the housing (10), or, alternatively (and preferably), can form an independent body of the others, which is coupled to the nebulizer (4) and / or to the disposable capsule (1) and / or to the housing (10) for the administration of the medicine in each use of the nebulizer device, proceeding after the application of said medicine, to separate the parts that make up the nebulizer device, discard the disposable capsule (1) already empty, and clean and disinfect the nozzle (5) and the nebulizer (4). twenty

    According to a preferred mode of use of the nebulizer device, it is envisaged that the user of the nebulizer device will make the nebulizer (4) of its nebulizer device available to a specialized healthcare company, so that said company is responsible for cleaning and disinfecting the nebulizer (4). 25

    This saves time for the user, who does not need to personally clean the nebulizer (4) of his nebulizer device, taking care of such cleaning and disinfection by a professional agent, or a company providing specialized health services. 30

    For the correct administration of the medication in each use of the nebulizer device, the user acquires a disposable capsule (1) containing the
    appropriate medicine, in the appropriate dose in each case, and proceeds to couple the nebulizer (4) in the lower cylindrical part of the disposable capsule (1).

    The punch (6) of the nebulizer (4) then perforates both the outer seal (3) of the lower part of the disposable capsule (1) (in the case that it has not been manually removed 5), as well as each inner seal (2 ) of said disposable capsule (1) (in those embodiments in which the disposable capsule (1) comprises at least one internal seal (2)). In this way, the mixture of the different phases in which the medicine could be stored separately inside the disposable capsule (1) is produced, and then the mixture of the medicine flows, through the inside of the punch (6) towards the mesh (8) that is driven by the piezoelectric (7). For this purpose, the punch (6) comprises a hollow geometry with a cutting end.

    Figures 1, 2 and 3 represent different variants of the first embodiment of the nebulizer device. These figures show the main components of the nebulizer device, and do not represent the housing (10).

    The variants shown in Figures 1, 2 and 3 differ only in the mode of coupling between the nebulizer (4) and the disposable capsule (1).
     twenty
    The coupling between the nebulizer (4) and the disposable capsule (1) is preferably threaded (see Figure 2). Alternatively (see figure 3), the nebulizer (4) can be pivotally coupled to the disposable capsule (1), so that it rotates by means of a hinge and is coupled by pressure and tightened to said disposable capsule (1). 25

    The mesh (8) of the nebulizer (4) is actuated by the piezoelectric (7), preferably by pressing a switch, button or other means of activation / deactivation (9) comprised in the housing (10) of the nebulizer device.
     30
    The piezoelectric (7) drives the vibrating mesh (8) producing a high frequency vibration (~ 180 kHz) in said mesh (8).

    Eventually it may be necessary to shake the disposable capsule (1) prior to administration of the medication, to facilitate proper mixing and homogenization of the medication.

    The nozzle (5) can be discarded (if it is a body independent of the rest of the elements of the device) after each use, or it can be reused.

    In figure 1 the nozzle (5) is shown as a body independent of the rest of the elements of the nebulizer device; In this case, the nozzle (5) is coupled to the nebulizer (4) and the disposable capsule (1). Said coupling can be made in a threaded manner, by means of a thread existing at the end of the nozzle (5) that is coupled to the rest of the nebulizer device, by twisting the nozzle (5), either to the nebulizer (4), or to the capsule disposable (1).

    Alternatively, the coupling between the nozzle (5) and the rest of the nebulizer device 15 can be carried out differently from the threading, for example, by pressure and tightening.

    Alternatively, the nozzle (5) can be coupled to the housing (10) of the nebulizer device, according to the coupling forms described. twenty

    Figure 4 shows a first type of housing (10) for a nebulizer device, in which the main components of the nebulizer device object of the present invention can be integrated. The housing (10) of the nebulizer device comprises means of activation / deactivation (9), such as a button, which when pressed, causes the piezoelectric (7) of the nebulizer (4) to activate the vibrating mesh (8) for correct application of the medicine.

    Figure 5 shows an assembly perspective of the main components of the nebulizer device object of the present invention, in the housing (10) shown in Figure 30 above.

    Figure 6 shows an assembly perspective of the main components of the nebulizer device (according to a second embodiment of said nebulizer device) in a second type of housing (10).

    In said second embodiment of the nebulizer device shown in Figure 6, the disposable capsule (1) does not have an angled geometry, and comprises an upper part in a preferably vertical conical shape and a lower part in a vertical cylindrical shape, which is inserted in a housing (10) of the nebulizer device, which in this case forms a single body with the nozzle (5).
     10
    By inserting the disposable capsule (1) into the nebulizer device, the punch (6) of the nebulizer (4) pierces an internal seal (2) of the disposable capsule (1), thereby accessing the medicament contained in said disposable capsule (1) ).

    Pressing on / off means (9) such as a button 15 comprised in the housing (10) of the nebulizer device activates the piezoelectric (7) of the nebulizer (4) which in turn drives the vibrating mesh (8) .
    权利要求:
    Claims (16)
    [1]

    1. Vibrating mesh nebulizer device, for medicament application, comprising a housing (10), a nozzle (5), a nebulizer (4) and a chamber that houses a medicament, characterized in that said chamber 5 which houses a medicament it is a disposable capsule (1) that forms an independent and removable body from the housing (10) of the nebulizer device, wherein said disposable capsule (1) comprises means for fixing to the nebulizer (4) and to the housing (10), where those mentioned fixing means allow the disposable capsule (1) to be attached / uncoupled to the nebulizer device 10.

    [2]
    2. Nebulizer device according to claim 1, characterized in that the nebulizer (4) comprises a piezoelectric (7) and a vibrating mesh (8) driven by the piezoelectric (7). fifteen

    [3]
    3. Nebulizer device according to claim 2, characterized in that the housing (10) comprises means for activating / deactivating (9) the piezoelectric (7) that drives the vibrating mesh (8) of the nebulizer (4).
     twenty
    [4]
    4. Nebulizer device according to claim 1, characterized in that the nozzle (5) comprises coupling / decoupling means to the nebulizer (4) and / or to the disposable capsule (1).

    [5]
    5. Nebulizer device according to claim 1, characterized in that the nozzle (5) comprises coupling / decoupling means to the housing (10) of the device.

    [6]
    6. Nebulizer device according to claims 4 and 5, characterized in that the coupling means of the nozzle (5) are selected from:
    to. a thread at the end of the nozzle (5) that connects with the housing (10) or with the nebulizer (4) or with the disposable capsule (1);
    b. a tightening diameter at the end of the nozzle (5) that connects with the housing (10) or with the nebulizer (4) or with the disposable capsule (1), providing a pressure coupling.
     5
    [7]
    7. Nebulizer device according to claim 1, characterized in that the nozzle (5) forms an integral part of the housing (10).

    [8]
    A nebulizer device according to claim 1, characterized in that the disposable capsule (1) comprises an external seal (3) for sealing the medicament inside it.

    [9]
    A nebulizer device according to claim 1, characterized in that the disposable capsule (1) comprises at least one internal seal (2), for sealing the medicine inside it and / or separating different phases 15 of the medicine it houses in its interior.

    [10]
    10. Nebulizer device according to claim 9, characterized in that the medicament housed inside the disposable capsule (1) comprises at least two distinct phases selected from:
    to. liquid phases;
    b. combination of liquid and solid phases;
    each of said phases located on a different side of an internal seal 25 (2).

    [11]
    11. Nebulizer device according to claim 1, characterized in that the disposable capsule (1) comprises a geometry with a vertical conical top and a cylindrical bottom. 30

    [12]
    12. Nebulizer device according to claim 11, characterized in that the disposable capsule (1) comprises a conical shaped bent geometry
    vertical at the top, and oblique cylinder shape or horizontal at the bottom.

    [13]
    13. Nebulizer device according to claim 11, characterized in that the cylindrical lower part of the disposable capsule (1) is arranged in a vertical position.

    [14]
    14. Nebulizer device according to claim 1, characterized in that the nebulizer (4) comprises a punch (6) with a cutting geometry at one end, perforating an external seal (3) of the disposable capsule (1) 10 and / or at least one internal seal (2) of the disposable capsule (1), where the geometry of said punch (6) is hollow, allowing the medication to flow through the punch (6), into the mesh (8) of the nebulizer ( 4).

    [15]
    15. Nebulizer device according to claim 1, characterized in that the nebulizer (4) is coupled to the disposable capsule (1) by means of a coupling selected from:
    to. threaded coupling;
     twenty
    b. pressure coupling and tightening.

    [16]
    16. Nebulizer device according to claim 1, characterized in that the nebulizer (4) is connected by a hinge to the disposable capsule (1).
      25
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    法律状态:
    2017-01-31| FG2A| Definitive protection|Ref document number: 2567954 Country of ref document: ES Kind code of ref document: B1 Effective date: 20170131 |
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    优先权:
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    ES201431415A|ES2567954B1|2014-09-26|2014-09-26|Nebulizer device|ES201431415A| ES2567954B1|2014-09-26|2014-09-26|Nebulizer device|
    ES14902813T| ES2824259T3|2014-09-26|2014-09-29|Nebulizer device|
    US15/514,057| US11185646B2|2014-09-26|2014-09-29|Nebuliser device|
    JP2017535967A| JP2017529221A|2014-09-26|2014-09-29|Inhaler|
    EP14902813.6A| EP3199191B1|2014-09-26|2014-09-29|Nebuliser device|
    AU2014407464A| AU2014407464B2|2014-09-26|2014-09-29|Nebuliser device|
    PCT/ES2014/070740| WO2016046423A1|2014-09-26|2014-09-29|Nebuliser device|
    CA2962550A| CA2962550C|2014-09-26|2014-09-29|Nebuliser device|
    RU2017114393A| RU2708821C2|2014-09-26|2014-09-29|Aerosol apparatus|
    US17/519,014| US20220054776A1|2014-09-26|2021-11-04|Nebuliser Device|
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